Obagi Medical
Obagi Retinol 0.5 28g
Obagi Retinol 0.5 28g
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Obagi Retinol 0.5 is a mid-strength retinol formulation using a controlled-release delivery system to minimise irritation while maintaining clinical effectiveness. At 0.5%, this formulation is appropriate for patients who have established retinoid tolerance and are ready to advance beyond starter-level concentrations without transitioning to a prescription product.
What it does:
- Delivers 0.5% retinol via a controlled-release system that slows skin absorption — reducing peak concentration and mitigating retinoid dermatitis risk
- Minimises the appearance of blemishes, fine lines, and wrinkles with minimal irritation
- Stimulates fibroblast activity and epidermal cell turnover, targeting fine lines, skin laxity, and surface texture
- Reduces comedone formation and normalises follicular keratinisation — useful for acne-prone or congested skin
- Vitamin E and shea butter buffer dryness and scaling during adaptation
Best for: Retinoid beginners seeking a mid-strength option, or those building tolerance before stepping up to Retinol 1.0 or clinically reviewed retinoid.
Clinician's Note
Clinician's Note
This product has been personally reviewed and selected by our founder based on clinical evidence, ingredient efficacy, and real-world patient outcomes. If you're unsure whether this is right for your skin, start a free written skin assessment and we'll recommend the best option for you.
How to Use
How to Use
Apply as directed by the product packaging or your clinician's recommendation. For best results, use consistently as part of a complete skincare routine. Not sure about application order? Ask our clinician — it's free.
Shipping & Returns
Shipping & Returns
Dispatch: 1-2 working days
Delivery: 2-4 working days (Royal Mail tracked)
Free shipping on orders over £100
Returns: Unused, unopened products may be returned within 7 days with prior approval. Prescription items cannot be returned once dispensed.
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Complete Your CSA Routine
Retinoids work best as part of the CSA framework — add vitamin C for morning protection and SPF to shield retinoid-sensitised skin.


