Collection: Obagi Vitamin C Serums

The Obagi Professional-C serum range delivers pure L-ascorbic acid at clinical concentrations — 10%, 15%, and 20%. These are among the most potent vitamin C serums available, providing antioxidant protection, collagen stimulation, and visible brightening of uneven skin tone.

Available in three strengths to suit your skin's tolerance and goals.

Pharmaceutical-Grade Vitamin C — Proven Antioxidant Protection

The Obagi Professional-C Serum range delivers L-ascorbic acid — the most bioavailable and clinically studied form of vitamin C — at pharmaceutical-grade purity. Unlike many high-street vitamin C products, Obagi formulates at a stable low pH to ensure maximum penetration and antioxidant efficacy. Available in three strengths (10%, 15%, and 20%), the range allows you to choose the right concentration for your skin type and build tolerance over time.

As a clinician, I consider a well-formulated vitamin C serum to be one of the three non-negotiable pillars of any serious skincare routine — alongside a retinoid and broad-spectrum SPF. Obagi Professional-C offers genuine pharmaceutical-grade L-ascorbic acid at concentrations that make a measurable difference to photoprotection, collagen synthesis, and pigmentation. This is not a cosmetic vitamin C — it is a clinical-grade active. Explore the full Obagi Medical range to see how it fits into a complete protocol.

Vitamin C + SPF Daily Defence Protocol

Pair your Obagi Professional-C Serum with a high-protection SPF for the ultimate daily defence against UV damage, free radicals, and premature ageing. Vitamin C boosts the efficacy of sunscreen by neutralising free radicals that slip past UV filters — together they offer significantly greater photoprotection than either product alone.

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Clinician's Pick

Start at 15% — Then Progress if Your Skin Tolerates It

For most patients, I recommend starting with the Professional-C Serum 15%. It delivers a clinically meaningful concentration of L-ascorbic acid without the tingling or irritation that some people experience at 20%. Use it every morning for 2–3 months, and if your skin tolerates it well with no sensitivity, step up to the 20% for maximum antioxidant protection. The 10% is best reserved for genuinely sensitive skin or those new to active skincare entirely.

— Mark Taylor, MSurg, INP, RMN

  • L-Ascorbic Acid

    The gold-standard form of vitamin C for topical skincare. L-ascorbic acid is the most bioavailable and extensively researched antioxidant, clinically proven to neutralise free radicals, stimulate collagen synthesis, inhibit melanin production, and enhance the photoprotective effect of sunscreen. Obagi formulates at a low pH to maximise skin penetration.

  • Hyaluronic Acid

    A powerful humectant that holds up to 1,000 times its weight in water. In the Professional-C formulations, hyaluronic acid provides immediate hydration and helps to buffer the low-pH L-ascorbic acid, reducing the risk of irritation while maintaining a plump, dewy finish after application.

  • Zinc

    An essential trace mineral with anti-inflammatory and antioxidant properties. Zinc supports the skin's natural repair processes and works synergistically with vitamin C to strengthen the skin's defence against environmental damage and UV-induced oxidative stress.

  • Vitamin E (Tocopherol)

    A lipid-soluble antioxidant that works in concert with vitamin C to provide enhanced photoprotection. When combined, vitamins C and E offer synergistic antioxidant defence — vitamin C regenerates oxidised vitamin E, creating a self-renewing protective cycle on the skin's surface.

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How to Use Vitamin C in Your AM Routine

Morning routine: Cleanse → Obagi Professional-C Serum (4–5 drops, press into skin) → Wait 1–2 minutes to absorb → Hydrating moisturiser → Broad-spectrum SPF 30+

Important: Vitamin C is a morning active. Apply it before your SPF every day for maximum antioxidant defence. Allow it to absorb fully before layering other products — this ensures the low-pH formula penetrates effectively before being buffered by your moisturiser.

Tip: If you are also using a retinoid at night, vitamin C in the morning and retinoid in the evening is the gold-standard split. Do not layer vitamin C and retinoids in the same routine as the pH requirements conflict.

Obagi Vitamin C — Frequently Asked Questions

What percentage of vitamin C should I use?

For most skin types, 15% is the ideal starting point — it delivers a clinically effective concentration without excessive irritation. If your skin is sensitive or you have never used active skincare, start at 10%. After 2–3 months at 15% with good tolerance, you can step up to 20% for maximum antioxidant protection. There is limited clinical benefit above 20%, so the Professional-C 20% represents the ceiling of what is useful in a topical serum.

Can I use vitamin C alongside retinoids?

Yes, but not in the same routine. Vitamin C works best at a low pH (around 2.5–3.5), while retinoids perform optimally at a slightly higher pH. Applying them together can reduce the efficacy of both. The best approach is vitamin C in the morning and your retinoid (Crystal Retinal, retinol, or Advanced-Protocol Retinoid) in the evening. This way each active works at its optimal pH, and you get comprehensive daytime antioxidant protection plus overnight cell renewal.

Why has my vitamin C serum changed colour?

L-ascorbic acid is inherently unstable and oxidises when exposed to air, light, and heat. If your serum has turned from clear or pale gold to a deep orange or brown, it has oxidised significantly and should be replaced. To extend shelf life, store your Obagi Professional-C in a cool, dark place (a bathroom cabinet is fine), keep the cap tightly sealed, and use it within 3 months of opening. A slight deepening in colour is normal over time, but a dramatic change indicates reduced efficacy.

How does Obagi Professional-C compare to Medik8 vitamin C?

Both are excellent clinical-grade vitamin C products, but they take different approaches. Obagi uses pure L-ascorbic acid at a low pH for maximum potency and penetration — ideal for those who want the strongest direct antioxidant hit. Medik8's C-Tetra range uses tetrahexyldecyl ascorbate, a lipid-soluble vitamin C derivative that is gentler and more stable but requires conversion in the skin. If your skin tolerates acids well, Obagi's L-ascorbic acid formulation is the more potent choice. If you have sensitive skin or find acids irritating, Medik8 may suit you better.

Do I still need vitamin C if I already use SPF?

Yes — SPF and vitamin C protect against UV damage through completely different mechanisms. Sunscreen filters and reflects UV radiation before it hits your skin, while vitamin C neutralises the free radicals that are generated by UV exposure that does get through. No sunscreen blocks 100% of UV, and free radical generation continues even after sun exposure ends. Using both together provides significantly greater photoprotection than either alone. Think of SPF as your shield and vitamin C as your repair crew. This combination is especially important if you are treating pigmentation or uneven tone.

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